Sourdough Pesto Grilled Cheese

Featured in: Weeknight Dinners

This elevated sourdough sandwich combines the tanginess of thick-cut sourdough bread with aromatic basil pesto and a luxurious blend of three cheeses: mozzarella, fontina, and sharp white cheddar. Spread softened butter on the exterior and pesto on the interior, layer the cheeses generously, then grill until the bread is golden and the cheese melts into creamy perfection. Total time: just 20 minutes.

Updated on Tue, 20 Jan 2026 15:34:00 GMT
Golden, crispy sourdough pesto grilled cheese sandwich oozing melty mozzarella, fontina, and cheddar on a wooden cutting board. Save
Golden, crispy sourdough pesto grilled cheese sandwich oozing melty mozzarella, fontina, and cheddar on a wooden cutting board. | milestonepan.com

The first time I made this pesto grilled cheese was actually an accident born of desperation. I was starving after a long day, craving comfort food but wanting something more exciting than plain grilled cheese. I spotted a jar of pesto in the fridge and decided to experiment, and that sandwich completely changed how I think about grilled cheese forever.

My roommate walked into the kitchen while I was making these and literally stopped in her tracks, asking what smelled so incredible. We ended up sitting on the kitchen floor eating them straight off the cutting board, burning our fingers because we could not wait for them to cool down. Now its our go-to comfort food for rainy days or when life just feels overwhelming.

Ingredients

  • Thick-cut sourdough bread: The sturdy texture and tangy flavor of sourdough creates the perfect foundation, holding up to all that cheese without getting soggy
  • Shredded mozzarella cheese: This provides that classic stretch and mild creaminess that balances the stronger flavors
  • Shredded fontina cheese: Fontina melts like a dream and adds this wonderful nuttiness that takes the sandwich to restaurant quality
  • Shredded sharp white cheddar: The sharpness cuts through the richness and adds a punch of flavor that keeps things interesting
  • Basil pesto: This is the secret weapon that elevates everything, adding aromatic brightness and herbaceous depth
  • Unsalted butter: Softened butter spreads evenly and helps achieve that golden, crispy exterior we all want

Instructions

Product image
Make fresh ice for iced coffee, cocktails, chilling ingredients, and keeping drinks cold while cooking.
Check price on Amazon
Prepare your bread slices:
Lay out all four slices of sourdough and spread half a tablespoon of softened butter on one side of each slice, making sure to cover the surface completely
Layer on the pesto:
Flip the bread over and spread about a tablespoon of basil pesto on the unbuttered side of two slices, going all the way to the edges
Add the cheese blend:
Evenly divide and sprinkle the mozzarella, fontina, and cheddar over those pesto-covered slices, making sure the cheese reaches the corners
Assemble the sandwiches:
Top each cheese-covered slice with a remaining bread slice, buttered side facing out, pressing down gently
Heat your pan:
Warm a large nonstick skillet or griddle over medium heat until hot but not smoking
Grill to perfection:
Carefully place the sandwiches in the skillet and cook for 3 to 4 minutes per side, pressing gently with a spatula, until golden and crisp
Rest and serve:
Remove from the pan and let them cool for 1 minute before slicing diagonally and serving warm
Product image
Make fresh ice for iced coffee, cocktails, chilling ingredients, and keeping drinks cold while cooking.
Check price on Amazon
Thick-cut sourdough pesto grilled cheese on a plate with a bowl of tomato soup for a cozy lunch. Save
Thick-cut sourdough pesto grilled cheese on a plate with a bowl of tomato soup for a cozy lunch. | milestonepan.com

This recipe has become my absolute favorite way to turn a regular Tuesday dinner into something that feels special. Theres something so satisfying about biting through that crispy, buttery bread and hitting that molten, pesto-infused cheese layer.

Choosing the Right Bread

Not all sourdough is created equal when it comes to grilled cheese. You want a loaf thats at least a day old and has a tight crumb, meaning the holes inside arent too large. I once used a really artisanal, holey sourdough and all my cheese melted right through onto the pan. A slightly denser sourdough will hold everything together while still giving you that signature tang and chew.

The Art of Cheese Blending

I used to just use whatever cheese I had on hand, usually just sharp cheddar, but once I started blending three different cheeses, everything changed. The mozzarella provides that incredible stretch, fontina adds sophisticated nuttiness, and sharp cheddar punches through with bold flavor. This combination works because each cheese brings something different to the party, creating layers of flavor that keep your palate interested.

Make It Your Own

While this recipe is pretty perfect as is, there are so many ways to customize it based on what you love or have in your fridge. I have made countless variations depending on my mood and the season.

  • Add thin tomato slices for extra moisture and sweetness
  • Throw in fresh baby spinach for a pop of color and nutrition
  • Try swapping in Gruyère or provolone if you want to experiment with different flavor profiles
Product image
Deep clean greasy stovetops, countertops, sinks, and tiles using powerful steam after everyday cooking.
Check price on Amazon
Close-up of a sourdough pesto grilled cheese, highlighting golden-brown crust and melted cheese blend between the slices. Save
Close-up of a sourdough pesto grilled cheese, highlighting golden-brown crust and melted cheese blend between the slices. | milestonepan.com

I hope this recipe brings you as much comfort and joy as its brought me over the years. Theres something magical about the combination of warm, melty cheese and aromatic basil that just makes everything better.

Recipe FAQs

Can I use different cheeses?

Absolutely. Gruyère, provolone, or a combination of your favorites work wonderfully. The key is choosing cheeses that melt well and complement the basil pesto.

How do I prevent the bread from burning?

Use medium heat and cook for 3–4 minutes per side. Press gently with a spatula to ensure even contact with the pan. If the exterior browns too quickly, lower the heat slightly and extend cooking time.

What pesto should I use?

Store-bought pesto works perfectly for convenience. Homemade basil pesto offers more control over flavors and allows you to ensure it's nut-free if needed for allergies.

Can I add vegetables?

Yes. Thin tomato slices, baby spinach, or roasted red peppers add wonderful flavor and texture. Layer them on top of the pesto before adding the cheese.

How do I make this vegan?

Substitute plant-based butter, dairy-free cheese alternatives, and vegan pesto (ensure it's nut-free if needed). The cooking method remains identical.

What pairs well as a side?

A crisp side salad or warm tomato soup complements this sandwich beautifully, creating a satisfying and balanced meal.

Sourdough Pesto Grilled Cheese

Thick-cut sourdough with aromatic basil pesto and a blend of melty cheeses, grilled until golden and crisp.

Prep Time
10 min
Time to Cook
10 min
Time Needed
20 min
Created by Caleb Barnes


Skill Level Easy

Cuisine American

Servings Yielded 2 Number of Servings

Special Diets Meatless

What You'll Need

Bread

01 4 slices thick-cut sourdough bread

Cheese

01 1/2 cup shredded mozzarella cheese
02 1/2 cup shredded fontina cheese
03 1/2 cup shredded sharp white cheddar cheese

Spreads & Condiments

01 3 tablespoons basil pesto
02 2 tablespoons unsalted butter, softened

How To Make

Step 01

Prepare bread: Lay out the sourdough slices and spread 1/2 tablespoon of butter on one side of each slice.

Step 02

Apply pesto: Flip the bread over and spread approximately 1 tablespoon of basil pesto on the unbuttered side of two slices.

Step 03

Layer cheese: Evenly distribute the mozzarella, fontina, and cheddar cheese over the pesto-covered slices.

Step 04

Assemble sandwiches: Top with the remaining bread slices with the buttered side facing outward.

Step 05

Heat cooking surface: Heat a large nonstick skillet or griddle over medium heat.

Step 06

Grill sandwiches: Place the sandwiches in the skillet and cook for 3 to 4 minutes per side, pressing gently with a spatula, until the bread is golden and crisp and the cheese is fully melted.

Step 07

Rest and serve: Remove from the pan, let cool for 1 minute, then slice diagonally and serve warm.

Tools Needed

  • Nonstick skillet or griddle
  • Spatula
  • Bread knife
  • Cheese grater

Allergen Details

Review each ingredient for allergens and speak with your healthcare provider if you have questions.
  • Contains wheat from sourdough bread
  • Contains milk from cheese and butter
  • May contain tree nuts if pesto contains pine nuts

Nutrition (per serving)

For informational use only. Always consult with a health professional if needed.
  • Calorie Count: 480
  • Fats: 29 g
  • Carbohydrates: 36 g
  • Proteins: 19 g